null

SMILES: Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCNCC1)-c1ccccc1

InChI Key: InChIKey=ALWJBFDENBTFNM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 461257   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 1A2/2C18/2C19 (Homo sapiens (Human))	BDBM461257 (US10774056, Compound 006) Show SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCNCC1)-c1ccccc1 Show InChI InChI=1S/C22H23N5O/c23-19-8-6-17(16-4-2-1-3-5-16)14-20(19)26-22(28)18-7-9-21(25-15-18)27-12-10-24-11-13-27/h1-9,14-15,24H,10-13,23H2,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
REGENACY PHARMACEUTICALS, INC. US Patent					Assay Description For Cyp inhibition, human liver microsomes from BD Gentest were incubated with Compound 028 or Compound 032 (10, 3.33, 1.11, 0.37, 0.12, 0.04, 0.01 &...				US Patent US10774056 (2020)
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM461257 (US10774056, Compound 006) Show SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCNCC1)-c1ccccc1 Show InChI InChI=1S/C22H23N5O/c23-19-8-6-17(16-4-2-1-3-5-16)14-20(19)26-22(28)18-7-9-21(25-15-18)27-12-10-24-11-13-27/h1-9,14-15,24H,10-13,23H2,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
REGENACY PHARMACEUTICALS, INC. US Patent					Assay Description For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...				US Patent US10774056 (2020)
					More data for this Ligand-Target Pair