BDBM4617 1,6-naphthyridine deriv. 19::3-tert-butyl-1-{7-[(tert-butylcarbamoyl)amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-yl}urea::N-(tert-Butyl)-N-[7-(3-tert-butylureido)-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-yl]urea

SMILES: COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C

InChI Key: InChIKey=NKKGFYVJHBKKIU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4617   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4617 (1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4617 (1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4617 (1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair