null

SMILES: CC(C)n1c(COC2CCCCO2)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl

InChI Key: InChIKey=PPBUGSNWRZPWMZ-CKALXEAQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 462169   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM462169 ((Scheme A-9): Preparation of (3R,4R)-4-({4-[1-(aze...) Show SMILES CC(C)n1c(COC2CCCCO2)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C26H34ClFN6O5S/c1-15(2)34-20-11-16(10-18(28)25(20)31-22(34)14-39-23-6-4-5-9-38-23)24-17(27)12-29-26(32-24)30-19-7-8-33(13-21(19)35)40(3,36)37/h10-12,15,19,21,23,35H,4-9,13-14H2,1-3H3,(H,29,30,32)/t19-,21-,23?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...				US Patent US10766884 (2020) BindingDB Entry DOI: 10.7270/Q23F4SQG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM462169 ((Scheme A-9): Preparation of (3R,4R)-4-({4-[1-(aze...) Show SMILES CC(C)n1c(COC2CCCCO2)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C26H34ClFN6O5S/c1-15(2)34-20-11-16(10-18(28)25(20)31-22(34)14-39-23-6-4-5-9-38-23)24-17(27)12-29-26(32-24)30-19-7-8-33(13-21(19)35)40(3,36)37/h10-12,15,19,21,23,35H,4-9,13-14H2,1-3H3,(H,29,30,32)/t19-,21-,23?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XG9V9M
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM462169 ((Scheme A-9): Preparation of (3R,4R)-4-({4-[1-(aze...) Show SMILES CC(C)n1c(COC2CCCCO2)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C26H34ClFN6O5S/c1-15(2)34-20-11-16(10-18(28)25(20)31-22(34)14-39-23-6-4-5-9-38-23)24-17(27)12-29-26(32-24)30-19-7-8-33(13-21(19)35)40(3,36)37/h10-12,15,19,21,23,35H,4-9,13-14H2,1-3H3,(H,29,30,32)/t19-,21-,23?/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XG9V9M
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM462169 ((Scheme A-9): Preparation of (3R,4R)-4-({4-[1-(aze...) Show SMILES CC(C)n1c(COC2CCCCO2)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C26H34ClFN6O5S/c1-15(2)34-20-11-16(10-18(28)25(20)31-22(34)14-39-23-6-4-5-9-38-23)24-17(27)12-29-26(32-24)30-19-7-8-33(13-21(19)35)40(3,36)37/h10-12,15,19,21,23,35H,4-9,13-14H2,1-3H3,(H,29,30,32)/t19-,21-,23?/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...				US Patent US10766884 (2020) BindingDB Entry DOI: 10.7270/Q23F4SQG
					More data for this Ligand-Target Pair