BindingDB logo
myBDB logout

null

SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccc1

InChI Key: InChIKey=UXGYFNJNOZVAPL-LBPRGKRZSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464391   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM464391
PNG
(US10792283, Compound 1)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccc1
Show InChI InChI=1S/C22H18FN7/c1-12(27-21-17(11-24)20(25)29-22(26)30-21)16-9-14-7-8-15(23)10-18(14)28-19(16)13-5-3-2-4-6-13/h2-10,12H,1H3,(H5,25,26,27,29,30)/t12-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0430n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...

US Patent US10792283 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5KQH
More data for this
Ligand-Target Pair