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SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1cccc(F)c1

InChI Key: InChIKey=OAOUTMLTVSCQOV-NSHDSACASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464397   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM464397
PNG
(US10792283, Compound 5)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1cccc(F)c1
Show InChI InChI=1S/C22H17F2N7/c1-11(28-21-17(10-25)20(26)30-22(27)31-21)16-8-12-5-6-15(24)9-18(12)29-19(16)13-3-2-4-14(23)7-13/h2-9,11H,1H3,(H5,26,27,28,30,31)/t11-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...

US Patent US10792283 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5KQH
More data for this
Ligand-Target Pair