null
SMILES: Nc1nc(-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)c2cc([nH]c2n1)C1=CCN(CC1)C1COC1
InChI Key: InChIKey=LJODJUIHONTDMR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM465748 (2-(3-{2-amino-6-[1-(oxetan-3-yl)-1,2,3,6-tetrahydr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
CARNA BIOSCIENCES, INC. US Patent | Assay Description The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In... | US Patent US10793575 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK [C481S] (Homo sapiens (Human)) | BDBM465748 (2-(3-{2-amino-6-[1-(oxetan-3-yl)-1,2,3,6-tetrahydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a |
CARNA BIOSCIENCES, INC. US Patent | Assay Description The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc... | US Patent US10793575 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM465748 (2-(3-{2-amino-6-[1-(oxetan-3-yl)-1,2,3,6-tetrahydr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
CARNA BIOSCIENCES, INC. US Patent | Assay Description The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In... | US Patent US10793575 (2020) | |||||||||||
More data for this Ligand-Target Pair |