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SMILES: O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 466343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	25.4	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.80	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.30	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020)
					More data for this Ligand-Target Pair