null
SMILES: O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCOCC1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM466352 ((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Leo Pharma A/S US Patent | Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma... | US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM466352 ((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 10.8 | n/a | n/a | n/a | n/a |
Leo Pharma A/S US Patent | Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma... | US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM466352 ((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a |
Leo Pharma A/S US Patent | Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma... | US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM466352 ((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a |
Leo Pharma A/S US Patent | Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma... | US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC | |||||||||||
More data for this Ligand-Target Pair |