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SMILES: OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM466365 ((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...) Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466365 ((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...) Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	19.8	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM466365 ((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...) Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM466365 ((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...) Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair