null

SMILES: N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O

InChI Key: InChIKey=MQOWMDPWQJBNJZ-ZJXHWGHKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468958   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM468958 (1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...) Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O |r| Show InChI InChI=1S/C31H30F4N4O4/c32-20-5-7-24(33)23(11-20)28-26(36)12-22(16-43-28)38-14-18-4-6-21(10-19(18)15-38)39-9-8-31(42,30(39)41)29(40)37-13-17-2-1-3-25(34)27(17)35/h1-7,10-11,22,26,28,42H,8-9,12-16,36H2,(H,37,40)/t22-,26+,28-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.67	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...				US Patent US10807971 (2020) BindingDB Entry DOI: 10.7270/Q2Z89GGJ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Mus musculus (Mouse))	BDBM468958 (1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...) Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O |r| Show InChI InChI=1S/C31H30F4N4O4/c32-20-5-7-24(33)23(11-20)28-26(36)12-22(16-43-28)38-14-18-4-6-21(10-19(18)15-38)39-9-8-31(42,30(39)41)29(40)37-13-17-2-1-3-25(34)27(17)35/h1-7,10-11,22,26,28,42H,8-9,12-16,36H2,(H,37,40)/t22-,26+,28-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...				US Patent US10807971 (2020) BindingDB Entry DOI: 10.7270/Q2Z89GGJ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM468958 (1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...) Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O |r| Show InChI InChI=1S/C31H30F4N4O4/c32-20-5-7-24(33)23(11-20)28-26(36)12-22(16-43-28)38-14-18-4-6-21(10-19(18)15-38)39-9-8-31(42,30(39)41)29(40)37-13-17-2-1-3-25(34)27(17)35/h1-7,10-11,22,26,28,42H,8-9,12-16,36H2,(H,37,40)/t22-,26+,28-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...				US Patent US10807971 (2020) BindingDB Entry DOI: 10.7270/Q2Z89GGJ
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Mus musculus)	BDBM468958 (1-[2-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...) Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)N1CCC(O)(C(=O)NCc2cccc(F)c2F)C1=O |r| Show InChI InChI=1S/C31H30F4N4O4/c32-20-5-7-24(33)23(11-20)28-26(36)12-22(16-43-28)38-14-18-4-6-21(10-19(18)15-38)39-9-8-31(42,30(39)41)29(40)37-13-17-2-1-3-25(34)27(17)35/h1-7,10-11,22,26,28,42H,8-9,12-16,36H2,(H,37,40)/t22-,26+,28-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.46	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...				US Patent US10807971 (2020) BindingDB Entry DOI: 10.7270/Q2Z89GGJ
					More data for this Ligand-Target Pair