null

SMILES: C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C

InChI Key: InChIKey=PZHFIIDHSWYJHA-NXHLMBQGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 471064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM471064 (US10821115, Example 100077 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C36H46ClN3O6S/c1-23-7-5-16-36(43,19-33(41)39(3)4)30-12-9-27(30)20-40-21-35(15-6-8-25-17-28(37)11-13-29(25)35)22-46-32-14-10-26(18-31(32)40)34(42)38-47(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,43H,6-9,12,15,19-22H2,1-4H3,(H,38,42)/b16-5+/t23-,24+,27-,30+,35-,36+/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2020.127717 BindingDB Entry DOI: 10.7270/Q2MW2N34
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471064 (US10821115, Example 100077 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C36H46ClN3O6S/c1-23-7-5-16-36(43,19-33(41)39(3)4)30-12-9-27(30)20-40-21-35(15-6-8-25-17-28(37)11-13-29(25)35)22-46-32-14-10-26(18-31(32)40)34(42)38-47(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,43H,6-9,12,15,19-22H2,1-4H3,(H,38,42)/b16-5+/t23-,24+,27-,30+,35-,36+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.409	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471064 (US10821115, Example 100077 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C36H46ClN3O6S/c1-23-7-5-16-36(43,19-33(41)39(3)4)30-12-9-27(30)20-40-21-35(15-6-8-25-17-28(37)11-13-29(25)35)22-46-32-14-10-26(18-31(32)40)34(42)38-47(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,43H,6-9,12,15,19-22H2,1-4H3,(H,38,42)/b16-5+/t23-,24+,27-,30+,35-,36+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.409	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471064 (US10821115, Example 100077 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C36H46ClN3O6S/c1-23-7-5-16-36(43,19-33(41)39(3)4)30-12-9-27(30)20-40-21-35(15-6-8-25-17-28(37)11-13-29(25)35)22-46-32-14-10-26(18-31(32)40)34(42)38-47(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,43H,6-9,12,15,19-22H2,1-4H3,(H,38,42)/b16-5+/t23-,24+,27-,30+,35-,36+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471064 (US10821115, Example 100077 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CC(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C36H46ClN3O6S/c1-23-7-5-16-36(43,19-33(41)39(3)4)30-12-9-27(30)20-40-21-35(15-6-8-25-17-28(37)11-13-29(25)35)22-46-32-14-10-26(18-31(32)40)34(42)38-47(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,43H,6-9,12,15,19-22H2,1-4H3,(H,38,42)/b16-5+/t23-,24+,27-,30+,35-,36+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair