BDBM47146 US8957073, 4.14::US8957073, 4.45::US9718803, 4.45
SMILES: COc1cccc(n1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
InChI Key: InChIKey=ZFTJTNWIESVCOY-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM47146 (US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.00120 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD... | US Patent US8957073 (2015) BindingDB Entry DOI: 10.7270/Q2PR7TPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM47146 (US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.00100 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien... | US Patent US9718803 (2017) BindingDB Entry DOI: 10.7270/Q2J968DN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM47146 (US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.00100 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien... | US Patent US9718803 (2017) BindingDB Entry DOI: 10.7270/Q2J968DN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM47146 (US8957073, 4.14 | US8957073, 4.45 | US9718803, 4.4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.00120 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD... | US Patent US8957073 (2015) BindingDB Entry DOI: 10.7270/Q2PR7TPZ | |||||||||||
More data for this Ligand-Target Pair |