null
SMILES: Nc1ncnc2n(C[C@@H]3SSC[C@H]3O)nc(-c3ccc(Oc4ccccc4)cc3)c12
InChI Key: InChIKey=UORAPQCBWYIISR-SJORKVTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Yes (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Yes (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fgr (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Blk (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn [Y531F] (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50: Methods for In Vitro Evaluation Assays known in the art for testing compounds are used to test compounds of this invention and to assess the bi... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine kinase 6 (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 21: This assay is based on a competitive binder which can interact with a latent pocket formed only in the inactive state of the kinase. A... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 2 of Tyrosine-protein kinase Fyn (T) (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description IC50 Table 22: This assay referred to as FlashPlate-based Protein Kinase Assay uses recombinant protein kinase and ATP concentration corresponding to... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity mitogen-activated protein kinase kinase 5 (Homo sapiens (Human)) | BDBM473174 ((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a |
SABILA BIOSCIENCES LLC US Patent | Assay Description Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an... | US Patent US10844038 (2020) | |||||||||||
More data for this Ligand-Target Pair |