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SMILES: CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)cc1F

InChI Key: InChIKey=JZZYDHBRNWDRLR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 473596   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473596
PNG
(US10844062, Example 32)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)cc1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(9-16)26(38)37-21-11-20(18(28)10-19(21)29)36-24-17(7-4-8-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)
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US Patent
n/an/a 29n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)

More data for this
Ligand-Target Pair