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SMILES: CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key: InChIKey=LMKUUFQEMUNYQQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 473607   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473607
PNG
(US10844062, Example 43)
Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H19F3N8O/c1-27(2,11-31)15-8-14(9-16(28)10-15)26(39)37-19-6-5-18(29)22(20(19)30)38-24-17(4-3-7-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)
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US Patent
n/an/a 127n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair