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SMILES: Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=XRVJDRXCRASQPQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 473637   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473637
PNG
(US10844062, Example 73)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-18-7-6-15(10-17(18)23(36)35-14-4-1-3-13(9-14)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
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US Patent
n/an/a 52n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair