null

SMILES: CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12

InChI Key: InChIKey=XVIXQCFZHSLBTO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473702   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...				US Patent US10844067 (2020) BindingDB Entry DOI: 10.7270/Q2HQ4308
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...				US Patent US10844067 (2020) BindingDB Entry DOI: 10.7270/Q2HQ4308
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	26.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q28S4TVP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q28S4TVP
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q28S4TVP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM473702 (5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...) Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12 Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...				US Patent US10844067 (2020) BindingDB Entry DOI: 10.7270/Q2HQ4308
					More data for this Ligand-Target Pair