BDBM474315 7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyridin-6-yl)-2-((tetrahydrofuran-3-yl)methyl)-[l,2, 4]triazolo[1,5-c]pyrimidin-5-amine(isomer 1)::US10858365, Compound 105-1

SMILES: Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1

InChI Key: InChIKey=YEJJJXQNIXCTJY-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adenosine receptor A2a (Homo sapiens (Human))	BDBM474315 (7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyrid...) Show SMILES Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1 Show InChI InChI=1S/C24H22FN7O/c1-14-11-27-20-7-4-17(12-31(14)20)21-22(16-2-5-18(25)6-3-16)29-24(26)32-23(21)28-19(30-32)10-15-8-9-33-13-15/h2-7,11-12,15H,8-10,13H2,1H3,(H2,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...				US Patent US10858365 (2020)
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Homo sapiens (Human))	BDBM474315 (7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyrid...) Show SMILES Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1 Show InChI InChI=1S/C24H22FN7O/c1-14-11-27-20-7-4-17(12-31(14)20)21-22(16-2-5-18(25)6-3-16)29-24(26)32-23(21)28-19(30-32)10-15-8-9-33-13-15/h2-7,11-12,15H,8-10,13H2,1H3,(H2,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...				US Patent US10858365 (2020)
					More data for this Ligand-Target Pair
Adenosine A2a receptor (Mus musculus)	BDBM474315 (7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyrid...) Show SMILES Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1 Show InChI InChI=1S/C24H22FN7O/c1-14-11-27-20-7-4-17(12-31(14)20)21-22(16-2-5-18(25)6-3-16)29-24(26)32-23(21)28-19(30-32)10-15-8-9-33-13-15/h2-7,11-12,15H,8-10,13H2,1H3,(H2,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...				US Patent US10858365 (2020)
					More data for this Ligand-Target Pair
Adenosine receptors; A2a & A2b (Homo sapiens (Human))	BDBM474315 (7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyrid...) Show SMILES Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1 Show InChI InChI=1S/C24H22FN7O/c1-14-11-27-20-7-4-17(12-31(14)20)21-22(16-2-5-18(25)6-3-16)29-24(26)32-23(21)28-19(30-32)10-15-8-9-33-13-15/h2-7,11-12,15H,8-10,13H2,1H3,(H2,26,29)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...				US Patent US10858365 (2020)
					More data for this Ligand-Target Pair