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SMILES: C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 475679   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM475679 ((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair