BDBM475698 2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,4,4a,5,6,8-hexahydro-1H-2,7-naphthyridin-2-yl]-5-bromo-1,3,4-thiadiazole ::US10851116, Example 20

SMILES: CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1

InChI Key:

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM475698 (2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...) Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM475698 (2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...) Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	269	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475698 (2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...) Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM475698 (2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...) Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020)
					More data for this Ligand-Target Pair