BDBM476105 US10865208, Compound I-160::{(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1H-inden-5-ylsulfanyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate

SMILES: Nc1ncnc2n(nc(Sc3ccc4CCCc4c3)c12)[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)O1

InChI Key: InChIKey=RJMHDSDUKCLGLF-RRFJBIMHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human))	BDBM476105 (US10865208, Compound I-160 | {(2R,3S,5R)-5-[4-amin...) Show SMILES Nc1ncnc2n(nc(Sc3ccc4CCCc4c3)c12)[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)O1 |r| Show InChI InChI=1S/C19H22N6O5S2/c20-17-16-18(23-9-22-17)25(15-7-13(26)14(30-15)8-29-32(21,27)28)24-19(16)31-12-5-4-10-2-1-3-11(10)6-12/h4-6,9,13-15,26H,1-3,7-8H2,(H2,20,22,23)(H2,21,27,28)/t13-,14+,15+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human))	BDBM476105 (US10865208, Compound I-160 | {(2R,3S,5R)-5-[4-amin...) Show SMILES Nc1ncnc2n(nc(Sc3ccc4CCCc4c3)c12)[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)O1 |r| Show InChI InChI=1S/C19H22N6O5S2/c20-17-16-18(23-9-22-17)25(15-7-13(26)14(30-15)8-29-32(21,27)28)24-19(16)31-12-5-4-10-2-1-3-11(10)6-12/h4-6,9,13-15,26H,1-3,7-8H2,(H2,20,22,23)(H2,21,27,28)/t13-,14+,15+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
MILLENNIUM PHARMACEUTICALS, INC. US Patent					Assay Description The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ...				US Patent US10865208 (2020)
					More data for this Ligand-Target Pair