null

SMILES: COc1ccc(CS(=O)(=O)[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(CNC(=O)OC(C)(C)C)cc2)NC(=O)C(F)(F)c2cccc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)cc1

InChI Key: InChIKey=KMVSJWMDBAAPBC-WNQXLSPZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476636   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine protease HTRA1 (Homo sapiens (Human))	BDBM476636 (US10870623, Example 8) Show SMILES COc1ccc(CS(=O)(=O)[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(CNC(=O)OC(C)(C)C)cc2)NC(=O)C(F)(F)c2cccc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)cc1 Show InChI InChI=1S/C42H48ClF5N4O9S/c1-24(2)34(35(53)42(46,47)48)51-36(54)33-20-31(62(58,59)23-27-14-16-30(60-6)17-15-27)22-52(33)37(55)32(50-38(56)41(44,45)28-8-7-9-29(43)19-28)18-25-10-12-26(13-11-25)21-49-39(57)61-40(3,4)5/h7-17,19,24,31-34H,18,20-23H2,1-6H3,(H,49,57)(H,50,56)(H,51,54)/t31-,32+,33+,34+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US10870623 (2020)
					More data for this Ligand-Target Pair