null
SMILES: CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1cnc(cn1)N1CCCCC1
InChI Key: InChIKey=XDJGNPSZQSWJCV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM477065 (US10882859, Reference compound PF-06263276) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED US Patent | Assay Description The biochemical JAK family enzyme binding assays carried out at DiscoveRx. | US Patent US10882859 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM477065 (US10882859, Reference compound PF-06263276) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED US Patent | Assay Description The biochemical JAK family enzyme binding assays carried out at DiscoveRx. | US Patent US10882859 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM477065 (US10882859, Reference compound PF-06263276) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED US Patent | Assay Description The biochemical JAK family enzyme binding assays carried out at DiscoveRx. | US Patent US10882859 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM477065 (US10882859, Reference compound PF-06263276) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED US Patent | Assay Description The biochemical JAK family enzyme binding assays carried out at DiscoveRx. | US Patent US10882859 (2021) | |||||||||||
More data for this Ligand-Target Pair |