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SMILES: COc1cc(nnc1C)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1

InChI Key: InChIKey=GNKYCOIDYFVTDZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 477646   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Short transient receptor potential channel 6


(Homo sapiens (Human))		BDBM477646
PNG
(US10889568, Compound 21 | [4-(6-Amino-5-methoxy-py...)
Show SMILES COc1cc(nnc1C)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H26N4O4/c1-16-21(30-2)13-19(27-26-16)17-9-11-28(12-10-17)24(29)20-14-22(31-3)23(15-25-20)32-18-7-5-4-6-8-18/h4-8,13-15,17H,9-12H2,1-3H3
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US Patent
n/an/a 43n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...

US Patent US10889568 (2021)

More data for this
Ligand-Target Pair