BDBM477691 (R)—N8-(4-(chlorodifluoromethoxy)phenyl)-N6,4-dimethyl-3,4-dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazine-6,8-dicarboxamide::US10889571, Example 32::US10889571, Example 36::US10889571, Example 41

SMILES: C[C@@H]1COCc2nc3cc(cc(Br)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key: InChIKey=PEOQTXPZHPCTGG-SNVBAGLBSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477691   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human))	BDBM477691 ((R)—N8-(4-(chlorodifluoromethoxy)phenyl)-N6,4...) Show SMILES C[C@@H]1COCc2nc3cc(cc(Br)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| Show InChI InChI=1S/C19H15BrClF2N3O3/c1-10-8-28-9-16-25-15-7-11(6-14(20)17(15)26(10)16)18(27)24-12-2-4-13(5-3-12)29-19(21,22)23/h2-7,10H,8-9H2,1H3,(H,24,27)/t10-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Terns, Inc. US Patent					Assay Description ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...				US Patent US10889571 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human))	BDBM477691 ((R)—N8-(4-(chlorodifluoromethoxy)phenyl)-N6,4...) Show SMILES C[C@@H]1COCc2nc3cc(cc(Br)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| Show InChI InChI=1S/C19H15BrClF2N3O3/c1-10-8-28-9-16-25-15-7-11(6-14(20)17(15)26(10)16)18(27)24-12-2-4-13(5-3-12)29-19(21,22)23/h2-7,10H,8-9H2,1H3,(H,24,27)/t10-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	281	n/a	n/a	n/a	n/a	n/a	n/a
Terns, Inc. US Patent					Assay Description ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...				US Patent US10889571 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human))	BDBM477691 ((R)—N8-(4-(chlorodifluoromethoxy)phenyl)-N6,4...) Show SMILES C[C@@H]1COCc2nc3cc(cc(Br)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| Show InChI InChI=1S/C19H15BrClF2N3O3/c1-10-8-28-9-16-25-15-7-11(6-14(20)17(15)26(10)16)18(27)24-12-2-4-13(5-3-12)29-19(21,22)23/h2-7,10H,8-9H2,1H3,(H,24,27)/t10-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Terns, Inc. US Patent					Assay Description ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...				US Patent US10889571 (2021)
					More data for this Ligand-Target Pair