BDBM4793 4-Anilinopyrido[3,4-d]pyrimidine 20::Ethyl (2E)-4-{[4-(3-Bromoanilino)pyrido[3,4-d]pyrimidin-6-yl]amino}-4-oxo-2-butenoate::ethyl (2E)-3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl}carbamoyl)prop-2-enoate

SMILES: CCOC(=O)\C=C\C(=O)Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1

InChI Key: InChIKey=GSAMPEADMMYOLW-VOTSOKGWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4793 (4-Anilinopyrido[3,4-d]pyrimidine 20 | Ethyl (2E)-4...) Show SMILES CCOC(=O)\C=C\C(=O)Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 Show InChI InChI=1S/C19H16BrN5O3/c1-2-28-18(27)7-6-17(26)25-16-9-14-15(10-21-16)22-11-23-19(14)24-13-5-3-4-12(20)8-13/h3-11H,2H2,1H3,(H,21,25,26)(H,22,23,24)/b7-6+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...				J Med Chem 44: 429-40 (2001) Article DOI: 10.1021/jm000372i BindingDB Entry DOI: 10.7270/Q2HX19WB
					More data for this Ligand-Target Pair