BDBM481132 US10906896, Cpd 880

SMILES: Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cncc(c1)-c1ccccn1

InChI Key: InChIKey=JSAIPLUIDULEAD-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481132   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM481132 (US10906896, Cpd 880) Show SMILES Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cncc(c1)-c1ccccn1 Show InChI InChI=1S/C33H32N8O/c1-23-5-10-28(38-32(42)25-8-6-24(7-9-25)22-41-16-14-34-15-17-41)19-31(23)40-33-37-13-11-30(39-33)27-18-26(20-35-21-27)29-4-2-3-12-36-29/h2-13,18-21,34H,14-17,22H2,1H3,(H,38,42)(H,37,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM481132 (US10906896, Cpd 880) Show SMILES Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cncc(c1)-c1ccccn1 Show InChI InChI=1S/C33H32N8O/c1-23-5-10-28(38-32(42)25-8-6-24(7-9-25)22-41-16-14-34-15-17-41)19-31(23)40-33-37-13-11-30(39-33)27-18-26(20-35-21-27)29-4-2-3-12-36-29/h2-13,18-21,34H,14-17,22H2,1H3,(H,38,42)(H,37,39,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Homo sapiens (Human))	BDBM481132 (US10906896, Cpd 880) Show SMILES Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cncc(c1)-c1ccccn1 Show InChI InChI=1S/C33H32N8O/c1-23-5-10-28(38-32(42)25-8-6-24(7-9-25)22-41-16-14-34-15-17-41)19-31(23)40-33-37-13-11-30(39-33)27-18-26(20-35-21-27)29-4-2-3-12-36-29/h2-13,18-21,34H,14-17,22H2,1H3,(H,38,42)(H,37,39,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair