BDBM48250 6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine::6-phenyl-N-prop-2-enyl-3-pyridin-2-yl-1,2,4-triazin-5-amine::MLS000541554::N-allyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine::SMR000126412::allyl-[6-phenyl-3-(2-pyridyl)-1,2,4-triazin-5-yl]amine::cid_6413024

SMILES: C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1

InChI Key: InChIKey=CWJBBRRMMIMUDM-UHFFFAOYSA-N

Data: 1 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 48250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM48250 (6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...) Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1 Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.62E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM48250 (6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...) Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1 Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.15E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
TPA: Essential protein of the mitochondrial intermembrane space (Saccharomyces cerevisiae S288c)	BDBM48250 (6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...) Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1 Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	2.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2F18X6W
					More data for this Ligand-Target Pair
matrix metalloproteinase 1 (Homo sapiens (Human))	BDBM48250 (6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...) Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1 Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a
Sanford-Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2154FGT
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM48250 (6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...) Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1 Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.13E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair