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SMILES: Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1

InChI Key: InChIKey=OGIYYNGFEXVCHG-LBNVMWSVSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 483602   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483602
PNG
(US10927079, Compound 44b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28+/m0/s1
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PC cid
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US Patent
n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)

More data for this
Ligand-Target Pair