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SMILES: CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)C(F)(F)F)c(F)cc1C

InChI Key: InChIKey=YZWDVGGJQPLYLI-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 483965   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM483965
PNG
((S)-N-(2-fluoro-4-methyl-5-(7-methyl- 2-(methylami...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)C(F)(F)F)c(F)cc1C |r|
Show InChI InChI=1S/C22H22F4N6O/c1-11-6-17(23)18(30-21(33)32-5-4-14(10-32)22(24,25)26)8-15(11)16-7-13-9-28-20(27-3)31-19(13)29-12(16)2/h6-9,14H,4-5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)/t14-/m0/s1
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US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...

US Patent US10927111 (2021)

More data for this
Ligand-Target Pair