BDBM484621 US10934297, Compound 15

SMILES: Cn1cc(cn1)-c1cc2c(n[nH]c2cc1F)C(=O)NC1CCC(F)(F)CC1

InChI Key: InChIKey=QVKIODSKDACHKR-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM484621 (US10934297, Compound 15) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cc1F)C(=O)NC1CCC(F)(F)CC1 Show InChI InChI=1S/C18H18F3N5O/c1-26-9-10(8-22-26)12-6-13-15(7-14(12)19)24-25-16(13)17(27)23-11-2-4-18(20,21)5-3-11/h6-9,11H,2-5H2,1H3,(H,23,27)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description GSK3β: Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-respo...				US Patent US10934297 (2021)
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM484621 (US10934297, Compound 15) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cc1F)C(=O)NC1CCC(F)(F)CC1 Show InChI InChI=1S/C18H18F3N5O/c1-26-9-10(8-22-26)12-6-13-15(7-14(12)19)24-25-16(13)17(27)23-11-2-4-18(20,21)5-3-11/h6-9,11H,2-5H2,1H3,(H,23,27)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description DYRK1A: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response...				US Patent US10934297 (2021)
					More data for this Ligand-Target Pair