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BDBM4864 8-(4-Chloroanilino)-5-(4-pyridylmethyl)pyrido[2,3-d]-pyridazine::CGP79787 Analog 47::CHEMBL306284::N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,3-d]pyridazin-8-amine

SMILES: Clc1ccc(Nc2nnc(Cc3ccncc3)c3cccnc23)cc1

InChI Key: InChIKey=PAIOGTBZFHOIGA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4864   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4864
PNG
(8-(4-Chloroanilino)-5-(4-pyridylmethyl)pyrido[2,3-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3cccnc23)cc1
Show InChI InChI=1S/C19H14ClN5/c20-14-3-5-15(6-4-14)23-19-18-16(2-1-9-22-18)17(24-25-19)12-13-7-10-21-11-8-13/h1-11H,12H2,(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.70E+3n/an/an/an/a7.522



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4864
PNG
(8-(4-Chloroanilino)-5-(4-pyridylmethyl)pyrido[2,3-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3cccnc23)cc1
Show InChI InChI=1S/C19H14ClN5/c20-14-3-5-15(6-4-14)23-19-18-16(2-1-9-22-18)17(24-25-19)12-13-7-10-21-11-8-13/h1-11H,12H2,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Shanghai Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 17: 2126-33 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4864
PNG
(8-(4-Chloroanilino)-5-(4-pyridylmethyl)pyrido[2,3-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3cccnc23)cc1
Show InChI InChI=1S/C19H14ClN5/c20-14-3-5-15(6-4-14)23-19-18-16(2-1-9-22-18)17(24-25-19)12-13-7-10-21-11-8-13/h1-11H,12H2,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)

More data for this
Ligand-Target Pair