null

SMILES: CCn1cc(Nc2nc(N[C@@H]3CCCN(C3)C(=O)C(=C\C(C)C)\C#N)c3c(Cl)c[nH]c3n2)cn1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489572   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM489572 (US10961247, Ex. No. 178) Show SMILES CCn1cc(Nc2nc(N[C@@H]3CCCN(C3)C(=O)C(=C\C(C)C)\C#N)c3c(Cl)c[nH]c3n2)cn1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Daewoong Pharmaceutical Co., Ltd. US Patent					Assay Description JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...				US Patent US10961247 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM489572 (US10961247, Ex. No. 178) Show SMILES CCn1cc(Nc2nc(N[C@@H]3CCCN(C3)C(=O)C(=C\C(C)C)\C#N)c3c(Cl)c[nH]c3n2)cn1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Daewoong Pharmaceutical Co., Ltd. US Patent					Assay Description JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...				US Patent US10961247 (2021)
					More data for this Ligand-Target Pair