BDBM490777 US10968242, Example 3 Peak 4
SMILES: Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(S)(=O)O[C@@H]3[C@@H](O)[C@H](C[C@H]3n3cnc4c3nc[nH]c4=O)OP(S)(=O)O[C@H]2[C@@H]1F
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Stimulator of interferon genes protein (Human) | BDBM490777 (US10968242, Example 3 Peak 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga... | US Patent US10968242 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stimulator of interferon genes protein [H232R] (Homo sapiens (Human)) | BDBM490777 (US10968242, Example 3 Peak 4) | PDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K... | US Patent US10968242 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stimulator of interferon genes protein (Human) | BDBM490777 (US10968242, Example 3 Peak 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K... | US Patent US10968242 (2021) | |||||||||||
More data for this Ligand-Target Pair |