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SMILES: CN1CCC(CC1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)C(O)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=NNVXEGMVOBLWBC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492978   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM492978
PNG
(US10981898, Example 81)
Show SMILES CN1CCC(CC1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)C(O)(c2c(F)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H31Cl2FN2O5S/c1-29(37,19-10-12-34(2)13-11-19)21-14-24-27(25(33)15-21)30(38,20-5-8-22(31)9-6-20)35(28(24)36)17-18-4-7-23(32)16-26(18)41(3,39)40/h4-9,14-16,19,37-38H,10-13,17H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent


Assay Description
The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...

US Patent US10981898 (2021)

More data for this
Ligand-Target Pair