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SMILES: O[C@H]1CCCN[C@@H]1\C=C\Cn1cnc2c(Cl)c(Cl)cnc12

InChI Key: InChIKey=OSSNIVKJYZHOFN-NTYHVHHESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 493488   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ribose-phosphate pyrophosphokinase 1


(Homo sapiens (Human))		BDBM493488
PNG
(US10981917, Example 189)
Show SMILES O[C@H]1CCCN[C@@H]1\C=C\Cn1cnc2c(Cl)c(Cl)cnc12 |r|
Show InChI InChI=1S/C14H16Cl2N4O/c15-9-7-18-14-13(12(9)16)19-8-20(14)6-2-3-10-11(21)4-1-5-17-10/h2-3,7-8,10-11,17,21H,1,4-6H2/b3-2+/t10-,11+/m1/s1
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US Patent
n/an/a 300n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to confirm the biological activities of the compounds prepared in Examples, % inhibition or IC50 values of PRS enzyme (phosphoribosylpyropho...

US Patent US10981917 (2021)

More data for this
Ligand-Target Pair