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SMILES: Fc1ccc(Cl)cc1Cn1ccc(cc1=O)-c1c[nH]c2ncc(cc12)N1CCOCC1

InChI Key: InChIKey=ZGZZVLIMRLYGQI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 495253   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM495253
PNG
(1-(5-Chloro-2-fluorobenzyl)-4-(5-morpholino-1H-pyr...)
Show SMILES Fc1ccc(Cl)cc1Cn1ccc(cc1=O)-c1c[nH]c2ncc(cc12)N1CCOCC1
Show InChI InChI=1S/C23H20ClFN4O2/c24-17-1-2-21(25)16(9-17)14-29-4-3-15(10-22(29)30)20-13-27-23-19(20)11-18(12-26-23)28-5-7-31-8-6-28/h1-4,9-13H,5-8,14H2,(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<150n/an/an/an/an/an/a



AGV DISCOVERY; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE MONTPELLIER

US Patent


Assay Description
To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...

US Patent US10995089 (2021)

More data for this
Ligand-Target Pair