US11001586, Example 34 (2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)methanone
SMILES: CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
InChI Key: InChIKey=MSWOWUREQODTRO-LQGLAIQGSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human)) | BDBM497267 ((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill US Patent | Assay Description Activity Against Tyro3 Tyrosine Kinase. | US Patent US11001586 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Mer (Homo sapiens (Human)) | BDBM497267 ((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill US Patent | Assay Description Activity Against Mer Tyrosine Kinase. | US Patent US11001586 (2021) | |||||||||||
More data for this Ligand-Target Pair |