Found 6 hits for monomerid = 497276 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
Activity Against Mer Tyrosine Kinase. |
US Patent US11001586 (2021)
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
Activity Against Tyro3 Tyrosine Kinase. |
US Patent US11001586 (2021)
|
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM497276
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)| Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
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