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SMILES: CCS(=O)(=O)CCn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C

InChI Key: InChIKey=POKIPTXUKVWPSR-VKGTZQKMSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497554   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM497554
PNG
((1S,8R)-5-(2,6-difluorophenyl)-1-[6-[1-(2- ethylsu...)
Show SMILES CCS(=O)(=O)CCn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:26:27:20.19:36,23:22:20.19:36|
Show InChI InChI=1S/C28H28F2N6O2S/c1-4-39(37,38)11-10-36-16-17(13-32-36)23-14-31-15-24(33-23)28-9-8-19(27(28,2)3)18-12-22(34-35-26(18)28)25-20(29)6-5-7-21(25)30/h5-7,12-16,19H,4,8-11H2,1-3H3/t19-,28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...

US Patent US11008312 (2021)


BindingDB Entry DOI: 10.7270/Q24M97NW
More data for this
Ligand-Target Pair