BindingDB PrimarySearch

null

SMILES: CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O

InChI Key: InChIKey=BQJCRHHNABKAKU-KBQPJGBKSA-N

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 417 hits for monomerid = 50000092
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI Curated by ChEMBL					Assay Description Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane				Bioorg Med Chem 18: 5071-80 (2010) Article DOI: 10.1016/j.bmc.2010.05.071 BindingDB Entry DOI: 10.7270/Q2XP75XQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI Curated by ChEMBL					Assay Description Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membrane				Bioorg Med Chem 18: 5071-80 (2010) Article DOI: 10.1016/j.bmc.2010.05.071 BindingDB Entry DOI: 10.7270/Q2XP75XQ
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI Curated by ChEMBL					Assay Description Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane				Bioorg Med Chem 18: 5071-80 (2010) Article DOI: 10.1016/j.bmc.2010.05.071 BindingDB Entry DOI: 10.7270/Q2XP75XQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R.W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Rattus norvegicus (Rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Science 279: 77-81 (1998) Article DOI: 10.1126/science.279.5347.77 BindingDB Entry DOI: 10.7270/Q2X63KGH
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University Curated by ChEMBL					Assay Description In vivo binding affinity against sigma Opioid receptor was measured by using labeled ligand [3H]-SKF- 10,047 (1 nM)				J Med Chem 37: 3121-7 (1994) BindingDB Entry DOI: 10.7270/Q2PK0F6R
National Taiwan University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.09E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI Curated by ChEMBL					Assay Description Inhibition of electric eel AChE by Ellman's method				Bioorg Med Chem 18: 5071-80 (2010) Article DOI: 10.1016/j.bmc.2010.05.071 BindingDB Entry DOI: 10.7270/Q2XP75XQ
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	501	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]-diprenorphine from MOR (unknown origin)				Bioorg Med Chem Lett 29: 1938-1942 (2019) Article DOI: 10.1016/j.bmcl.2019.05.045 BindingDB Entry DOI: 10.7270/Q2FR0113
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	194	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat Mu-type opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 ...				J Med Chem 62: 4142-4157 (2019) Article DOI: 10.1021/acs.jmedchem.9b00219 BindingDB Entry DOI: 10.7270/Q23R0X7F
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	>593	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at human DOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...				J Med Chem 63: 1671-1683 (2020) Article DOI: 10.1021/acs.jmedchem.9b01818 BindingDB Entry DOI: 10.7270/Q2XG9VH9
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	147	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at human MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...				J Med Chem 63: 1671-1683 (2020) Article DOI: 10.1021/acs.jmedchem.9b01818 BindingDB Entry DOI: 10.7270/Q2XG9VH9
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Solute carrier family 22 member 1 (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
University Medicine Greifswald Curated by ChEMBL					Assay Description Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis				J Med Chem 62: 9890-9905 (2019) Article DOI: 10.1021/acs.jmedchem.9b01301 BindingDB Entry DOI: 10.7270/Q2QV3QSW
University Medicine Greifswald Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	124	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Agonist activity at rat MOR expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillat...				J Med Chem 62: 11054-11070 (2019) Article DOI: 10.1021/acs.jmedchem.9b00857 BindingDB Entry DOI: 10.7270/Q2VD72RV
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]-diprenorphin from human mu opioid receptor incubated for 1 hr				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126748 BindingDB Entry DOI: 10.7270/Q2M90D3M
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method				J Med Chem 59: 9255-9261 (2016) Article DOI: 10.1021/acs.jmedchem.6b00420 BindingDB Entry DOI: 10.7270/Q2JS9TXZ
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human delta opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01235 BindingDB Entry DOI: 10.7270/Q2FJ2MH3
TBA					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment measured after 90 mins by ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01235 BindingDB Entry DOI: 10.7270/Q2FJ2MH3
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	4.70	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human MOR expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by lumi...				Citation and Details Article DOI: 10.1039/d0md00104j BindingDB Entry DOI: 10.7270/Q2K64NQR
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
TBA					Assay Description Activity at human MOR expressed in CHOK1 cells co-expressing beta-arrestin2 EFC assessed as beta-arrestin2 EFC recruitment measured after 90 mins by ...				Citation and Details Article DOI: 10.1039/d0md00104j BindingDB Entry DOI: 10.7270/Q2K64NQR
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 min...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01235 BindingDB Entry DOI: 10.7270/Q2FJ2MH3
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human kappa opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01235 BindingDB Entry DOI: 10.7270/Q2FJ2MH3
TBA					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human delta opioid receptor assessed as inhibition of forskolin-induced cAMP accumulation				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00287 BindingDB Entry DOI: 10.7270/Q2J67MN8
TBA					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	204	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opioid receptor assessed as inhibition of forskolin-induced cAMP accumulation				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00287 BindingDB Entry DOI: 10.7270/Q2J67MN8
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	124	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat mu opioid receptor expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation cou...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01082 BindingDB Entry DOI: 10.7270/Q2NZ8CG1
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at MOR (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 3...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00694 BindingDB Entry DOI: 10.7270/Q2VM4H43
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at MOR (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 3...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00694 BindingDB Entry DOI: 10.7270/Q2VM4H43
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	417	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as Nb33 recruitment preincubated for 5 mins with coelenterazine foll...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00611 BindingDB Entry DOI: 10.7270/Q2N301V5
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	8.70	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as Galphai2 activation preincubated for 5 mins with coelenterazine f...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00611 BindingDB Entry DOI: 10.7270/Q2N301V5
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as arrestin-3 recruitment preincubated for 5 mins with coelenterazin...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00611 BindingDB Entry DOI: 10.7270/Q2N301V5
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (GUINEA PIG)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01915 BindingDB Entry DOI: 10.7270/Q22B931S
TBA					More data for this Ligand-Target Pair
Mu-type opioid receptor (MOUSE)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01915 BindingDB Entry DOI: 10.7270/Q22B931S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (MOUSE)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University La Sapienza Curated by ChEMBL					Assay Description In vitro agonistic activity against opioid receptor delta of mouse vas deferens				J Med Chem 48: 3372-8 (2005) Article DOI: 10.1021/jm040894o BindingDB Entry DOI: 10.7270/Q2X92C3R
University La Sapienza Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (GUINEA PIG)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
University La Sapienza Curated by ChEMBL					Assay Description In vitro agonistic activity against opioid receptor mu of guinea pig ileum				J Med Chem 48: 3372-8 (2005) Article DOI: 10.1021/jm040894o BindingDB Entry DOI: 10.7270/Q2X92C3R
University La Sapienza Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	484	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding				J Med Chem 50: 5176-82 (2007) Article DOI: 10.1021/jm070255o BindingDB Entry DOI: 10.7270/Q2RR202P
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (MOUSE)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	395	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at mu opioid receptor in Swiss mouse vas deferens assessed as inhibition of electrically-stimulated twitch				Bioorg Med Chem 16: 869-73 (2008) Article DOI: 10.1016/j.bmc.2007.10.030 BindingDB Entry DOI: 10.7270/Q2XW4KN1
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Stimulation of [35S]GTPgammaS binding to human recombinant MOR				J Med Chem 49: 5333-8 (2006) Article DOI: 10.1021/jm0604777 BindingDB Entry DOI: 10.7270/Q2WH2QSM
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	484	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Stimulation of [35S]GTP-gamma-S binding to human recombinant KOR				J Med Chem 49: 5333-8 (2006) Article DOI: 10.1021/jm0604777 BindingDB Entry DOI: 10.7270/Q2WH2QSM
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanit£ Curated by ChEMBL					Assay Description Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%				J Med Chem 30: 1906-10 (1987) BindingDB Entry DOI: 10.7270/Q2DB82D1
Istituto Superiore di Sanit£ Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type/Kappa-type/Mu-type opioid receptor (Homo sapiens (Human))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for irreversible antagonistic activity against opioid receptor in electrically stimulated longitudinal muscle of guinea pig ileum				J Med Chem 29: 1861-4 (1986) BindingDB Entry DOI: 10.7270/Q2HX1FW0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	194	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat MOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting a...				J Med Chem 56: 2139-49 (2013) Article DOI: 10.1021/jm400050y BindingDB Entry DOI: 10.7270/Q2K075MP
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	213	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig cerebellum				Bioorg Med Chem Lett 18: 6398-401 (2008) Article DOI: 10.1016/j.bmcl.2008.10.081 BindingDB Entry DOI: 10.7270/Q2DN45Z1
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (MOUSE)	BDBM50000092 ((-)-(etorphine) \| (-)-morphine \| (1S,5R,13R,14S)-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum				Bioorg Med Chem Lett 18: 6398-401 (2008) Article DOI: 10.1016/j.bmcl.2008.10.081 BindingDB Entry DOI: 10.7270/Q2DN45Z1
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair

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