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BDBM50000365 1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-propyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one::CHEMBL350321

SMILES: CCC[C@@H]1[C@@H](Cc2ccccc2N(CCN(C)C)C1=O)c1ccc(OC)cc1

InChI Key: InChIKey=VNXOLHFSXRJGAF-YADHBBJMSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50000365   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-gated L-type calcium channel


(Homo sapiens (Human))		BDBM50000365
PNG
(1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-p...)
Show SMILES CCC[C@@H]1[C@@H](Cc2ccccc2N(CCN(C)C)C1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C24H32N2O2/c1-5-8-21-22(18-11-13-20(28-4)14-12-18)17-19-9-6-7-10-23(19)26(24(21)27)16-15-25(2)3/h6-7,9-14,21-22H,5,8,15-17H2,1-4H3/t21-,22+/m1/s1
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n/an/an/a 250n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle.

J Med Chem 35: 780-93 (1992)


BindingDB Entry DOI: 10.7270/Q2K64H14
More data for this
Ligand-Target Pair