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BDBM50000376 1-(2-Dimethylamino-ethyl)-3-ethyl-4-(4-methoxy-phenyl)-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one::CHEMBL349193

SMILES: CC[C@@H]1[C@@H](Cc2c(cccc2C(F)(F)F)N(CCN(C)C)C1=O)c1ccc(OC)cc1

InChI Key: InChIKey=NRBGVEGWNHMORM-MOPGFXCFSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50000376   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-gated L-type calcium channel


(Homo sapiens (Human))		BDBM50000376
PNG
(1-(2-Dimethylamino-ethyl)-3-ethyl-4-(4-methoxy-phe...)
Show SMILES CC[C@@H]1[C@@H](Cc2c(cccc2C(F)(F)F)N(CCN(C)C)C1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C24H29F3N2O2/c1-5-18-19(16-9-11-17(31-4)12-10-16)15-20-21(24(25,26)27)7-6-8-22(20)29(23(18)30)14-13-28(2)3/h6-12,18-19H,5,13-15H2,1-4H3/t18-,19+/m1/s1
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n/an/an/a 600n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle.

J Med Chem 35: 780-93 (1992)


BindingDB Entry DOI: 10.7270/Q2K64H14
More data for this
Ligand-Target Pair