BDBM50000789 5-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yloxymethyl]-3-methylenetetrahydro-2-furanone::CHEMBL80531
SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)OC[C@@H]1CC(=C)C(=O)O1
InChI Key: InChIKey=AYJLAUNORPKULA-NOJKVUSZSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50000789 (5-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-az...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of [3H]DPDPE binding to guinea pig brain membrane Opioid receptor delta 1 at 1.0 nM | J Med Chem 35: 2374-84 (1992) BindingDB Entry DOI: 10.7270/Q2GH9JKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu/kappa/delta (Homo sapiens (Human)) | BDBM50000789 (5-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-az...) | PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid receptors | J Med Chem 35: 2374-84 (1992) BindingDB Entry DOI: 10.7270/Q2GH9JKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50000789 (5-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-az...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Displacement of 0.5 nM [3H]bremazocine from guinea pig brain membrane opioid receptor kappa with 100 nM DAGO and 100 nM DPDPE | J Med Chem 35: 2374-84 (1992) BindingDB Entry DOI: 10.7270/Q2GH9JKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50000789 (5-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-az...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description inhibition of 1.0 nM [3H]- DAGO binding to guinea pig brain membrane opioid receptor mu | J Med Chem 35: 2374-84 (1992) BindingDB Entry DOI: 10.7270/Q2GH9JKS | |||||||||||
More data for this Ligand-Target Pair |