BDBM50000933 CHEMBL92264::N-Adamantan-1-yl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide

SMILES: O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2

InChI Key: InChIKey=NBZFTGRXERNYTE-LGCQQFNGSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50000933   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Purinergic receptor P2Y12 (Homo sapiens (Human))	BDBM50000933 (CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...) Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:28:23:30:27.29.26,28:27:30:23.22.24| Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000933 (CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...) Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:28:23:30:27.29.26,28:27:30:23.22.24| Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Purinergic receptor P2Y12 (Homo sapiens (Human))	BDBM50000933 (CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...) Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:28:23:30:27.29.26,28:27:30:23.22.24| Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50000933 (CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...) Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:28:23:30:27.29.26,28:27:30:23.22.24| Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair