BDBM50001266 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid anion::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid(DCKA)::5,7-Dichloro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid::5,7-dichlorokynurenic acid::CHEMBL50267

SMILES: OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1

InChI Key: InChIKey=BGKFPRIGXAVYNX-UHFFFAOYSA-N

Data: 4 KI  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50001266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) BindingDB Entry DOI: 10.7270/Q2WM1F13
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM				Bioorg Med Chem Lett 3: 81-84 (1993) Article DOI: 10.1016/S0960-894X(00)80096-7 BindingDB Entry DOI: 10.7270/Q2MK6CTN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) BindingDB Entry DOI: 10.7270/Q2RR1X68
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita'degli Studi di Firenze Curated by ChEMBL					Assay Description Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligan...				J Med Chem 47: 262-72 (2003) Article DOI: 10.1021/jm030906q BindingDB Entry DOI: 10.7270/Q2668CM6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Universita' di Firenze Curated by ChEMBL					Assay Description Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...				J Med Chem 42: 2478-84 (1999) Article DOI: 10.1021/jm981102r BindingDB Entry DOI: 10.7270/Q20K27R0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability of compound to compete with [3H]-glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus				Bioorg Med Chem Lett 1: 455-460 (1991) Article DOI: 10.1016/S0960-894X(01)81105-7 BindingDB Entry DOI: 10.7270/Q26T0MJC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) BindingDB Entry DOI: 10.7270/Q2RR1X68
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Università di Messina Curated by ChEMBL					Assay Description Inhibition of specific binding of [3H]-glycine to NMDA receptors, in rat cortical membranes at 32 uM conc.				Bioorg Med Chem Lett 13: 443-6 (2003) BindingDB Entry DOI: 10.7270/Q2K073MV
					More data for this Ligand-Target Pair				3D Structure (crystal)