BindingDB PrimarySearch

BDBM50001747 (+)-Kadsurenone::(Kadsurenone)5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one::5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one::CHEMBL296958::KADSURENONE

SMILES: COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C

InChI Key: InChIKey=VDYACOATPFOZIO-UBWHGVKJSA-N

Data: 2 KI 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50001747
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	225	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhone-Poulenc Sante Curated by PDSP K_i Database									J Pharmacol Exp Ther 252: 1221-7 (1990) BindingDB Entry DOI: 10.7270/Q2JW8CC2
Rhone-Poulenc Sante Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	231	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhone-Poulenc Sante Curated by PDSP K_i Database									J Pharmacol Exp Ther 252: 1221-7 (1990) BindingDB Entry DOI: 10.7270/Q2JW8CC2
Rhone-Poulenc Sante Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2) (Ovis aries (Sheep))	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.46E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Nacional de Colombia Curated by ChEMBL					Assay Description Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA				Bioorg Med Chem Lett 19: 6922-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.069 BindingDB Entry DOI: 10.7270/Q2J1043X
Universidad Nacional de Colombia Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.				J Med Chem 30: 136-42 (1987) BindingDB Entry DOI: 10.7270/Q25T3M2X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.				J Med Chem 30: 136-42 (1987) BindingDB Entry DOI: 10.7270/Q25T3M2X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.				J Med Chem 30: 136-42 (1987) BindingDB Entry DOI: 10.7270/Q25T3M2X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Nacional de Colombia Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA				Bioorg Med Chem Lett 19: 6922-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.069 BindingDB Entry DOI: 10.7270/Q2J1043X
Universidad Nacional de Colombia Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.				J Med Chem 30: 136-42 (1987) BindingDB Entry DOI: 10.7270/Q25T3M2X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit PAF binding to rabbit platelet membrane				Bioorg Med Chem Lett 1: 327-332 (1991) Article DOI: 10.1016/S0960-894X(01)80818-0 BindingDB Entry DOI: 10.7270/Q2TM7BKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50001747 ((+)-Kadsurenone \| (Kadsurenone)5-Allyl-2-(3,4-dime...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
American Cyanamid Company Curated by ChEMBL					Assay Description Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma				J Med Chem 36: 580-90 (1993) BindingDB Entry DOI: 10.7270/Q2SX6C9X
American Cyanamid Company Curated by ChEMBL					More data for this Ligand-Target Pair