BDBM50004462 CHEMBL3233329
SMILES: NC(=S)Nc1nn2c([nH]c(=S)[nH]c2=O)c1Cc1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=XOIZLOGJRADKGZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thymidine Phosphorylase (TP) (Homo sapiens (Human)) | BDBM50004462 (CHEMBL3233329) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li... | Eur J Med Chem 78: 294-303 (2014) Article DOI: 10.1016/j.ejmech.2014.03.063 BindingDB Entry DOI: 10.7270/Q2SF2XP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine Phosphorylase (TP) (Homo sapiens (Human)) | BDBM50004462 (CHEMBL3233329) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidine to thymine after 4 to 20 mi... | Eur J Med Chem 78: 294-303 (2014) Article DOI: 10.1016/j.ejmech.2014.03.063 BindingDB Entry DOI: 10.7270/Q2SF2XP4 | |||||||||||
More data for this Ligand-Target Pair |