BDBM50005746 CHEMBL109382::CHEMBL33618::N-[9,10-Dioxo-6-(3-piperidin-1-yl-propionylamino)-9,10-dihydro-anthracen-2-yl]-3-piperidin-1-yl-propionamide
SMILES: O=C(CCN1CCCCC1)Nc1ccc2C(=O)c3cc(NC(=O)CCN4CCCCC4)ccc3C(=O)c2c1
InChI Key: InChIKey=GUSIRLMAICXUKB-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50005746 (CHEMBL109382 | CHEMBL33618 | N-[9,10-Dioxo-6-(3-pi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibitory activity of telomerase was measured using the TRAP assay. | J Med Chem 41: 4873-84 (1998) Article DOI: 10.1021/jm981067o BindingDB Entry DOI: 10.7270/Q2WW7GSD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50005746 (CHEMBL109382 | CHEMBL33618 | N-[9,10-Dioxo-6-(3-pi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 4.47E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of telomerase in Homo sapiens (human) A549 cells after 24 hr by TRAP assay | Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50005746 (CHEMBL109382 | CHEMBL33618 | N-[9,10-Dioxo-6-(3-pi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of telomerase activity | J Med Chem 41: 3253-60 (1998) Article DOI: 10.1021/jm9801105 BindingDB Entry DOI: 10.7270/Q2TX3G1R | |||||||||||
More data for this Ligand-Target Pair |