BDBM50005841 (exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-ylmethyl)-2-methoxy-benzamide::4-amino-5-chloro-N-[(1R,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl]-2-methoxybenzamide::CHEMBL37333
SMILES: COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12
InChI Key: InChIKey=GAYSOZKZPOVDSB-QMTHXVAHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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HTR4 (GUINEA PIG) | BDBM50005841 ((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]GR-113808 binding to 5HT4 receptor in guinea pig striatum at 500 nM | J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50005841 ((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor | J Med Chem 35: 1486-9 (1992) BindingDB Entry DOI: 10.7270/Q2CC11B3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50005841 ((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar rat | J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (RAT) | BDBM50005841 ((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 323 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonism at 5HT4 receptor in rat tunica muscularis mucosa | J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50005841 ((exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Binding affinity to dopamine receptor D2 | J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 | |||||||||||
More data for this Ligand-Target Pair |